Antioxidant and Antiinflammatory Activity of Vitex negundo
نویسندگان
چکیده
Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. The total methanol extract of the plant was standardized in terms of total polyphenols. The standardized extract in a dose of 100 mg/kg caused a comparable reduction in edema with that of diclofenac sodium (25 mg/kg) when evaluated for antiinflammatory activity by carrageenan-induced rat paw edema method. The extract also exhibited a strong free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl method and caused a significant reduction in the formation of thiobarbituric acid reacting substances when evaluated for its lipid peroxidation inhibitory activity. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity.
منابع مشابه
Antioxidant and Antiinflammatory Effects of Vitex Negundo on Freund’s Complete Adjuvant Induced Arthritis
Objective: Vitex negundo, commonly known as “nirgundi” is widely used in traditional as well as in folk medicines to cure many ailments such as fever, rheumatism, gum and skin diseases and liver disorders, etc. The present study evaluated the antioxidant potency of hydroethanolic extract of Vitex negundo leaves (VNE) in Freund’s complete adjuvant (FCA) induced arthritis. Methods: Acute oral tox...
متن کاملComparative Evaluation of Polyphenol Contents and Antioxidant Activities between Ethanol Extracts of Vitex negundo and Vitex trifolia L. Leaves by Different Methods
The in vitro antioxidant potential assay between ethanolic extracts of two species from the genus Vitex (Vitex negundo L. and Vitex trifolia L.) belonging to the Lamiaceae family were evaluated. The antioxidant properties of different extracts prepared from both plant species were evaluated by different methods. DPPH scavenging, nitric oxide scavenging, and β-carotene-linoleic acid and ferrous ...
متن کاملAntioxidant Potential of the Ethanol Extract of the Leaves of Vitex Negundo L
The antioxidant potential of the ethanol extract of Vitex negundo L. was evaluated by using 1, 1diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide, total antioxidant capacity and erythrocyte (RBC) membrane stabilization assays. The extract showed significant activities in all antioxidant assays compared to the reference antioxidant ascorbic acid in a dose dependent manner. In DPPH and hydrogen...
متن کاملAnti-inflammatory Activity of Extracts and Compounds from Vitex Negundo
RASADAH, M. A., FAREDIAH, A., WONG, C. L. & ONG, B. K. 2005. Antiinflammatory activity of extracts and compounds from Vitex negundo. The antiinflammatory activity of the leaf extract of Vitex negundo was investigated on topical administration using the TPA (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. The crude methanolic extract of V. negundo showed moderate inhibition (...
متن کاملVitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs.
BACKGROUND & OBJECTIVES Leaves of Vitex negundo (VN) have been investigated for their antiinflammatory activity in past, including its mechanism of action. However, nobody has evaluated its potential role as an adjuvant with standard anti-inflammatory therapy. Therefore, the present study was undertaken to investigate interaction of ethanolic leaf extract of VN Linn with standard anti-inflammat...
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